Intracellular Developmental Timers
نویسندگان
چکیده
منابع مشابه
The mystery of intracellular developmental programmes and timers.
There has been a revolution in understanding animal development in the last 25 years or so, but there is at least one area of development that has been relatively neglected and therefore remains largely mysterious. This is the intracellular programmes and timers that run in developing precursor cells and change the cells over time. The molecular mechanisms underlying these programmes are largel...
متن کاملCis-Regulatory Timers for Developmental Gene Expression
How does a fertilized egg decode its own genome to eventually develop into a mature animal? Each developing cell must activate a battery of genes in a timely manner and according to the function it will ultimately perform, but how? During development of the notochord--a structure akin to the vertebrate spine--in a simple marine invertebrate, an essential protein called Brachyury binds to specif...
متن کاملDevelopmental decline in neuronal regeneration by the progressive change of two intrinsic timers.
Like mammalian neurons, Caenorhabditis elegans neurons lose axon regeneration ability as they age, but it is not known why. Here, we report that let-7 contributes to a developmental decline in anterior ventral microtubule (AVM) axon regeneration. In older AVM axons, let-7 inhibits regeneration by down-regulating LIN-41, an important AVM axon regeneration-promoting factor. Whereas let-7 inhibits...
متن کاملRC Timers and Timing Circuits
Timers and timing circuits are used in a wide variety of applications. From short time delays of a few nanoseconds used in digital circuitry and computers, to long periods of thousands of hours, used to control daily, weekly, or yearly events, electronic circuits can provide this function reliably, accurately and repeatably, with no need to provide any user input or monitoring once the time has...
متن کاملComplex Contagions with Timers
There has been a great deal of effort to try to model social influence-including the spread of behavior, norms, and ideas-on networks. Most models of social influence tend to assume that individuals react to changes in the states of their neighbors without any time delay, but this is often not true in social contexts, where (for various reasons) different agents can have different response time...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cold Spring Harbor Symposia on Quantitative Biology
سال: 2007
ISSN: 0091-7451
DOI: 10.1101/sqb.2007.72.007